Nature, 2007-01, Vol.445 (7125), p.311-314
2007
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Sonic hedgehog function in chondrichthyan fins and the evolution of appendage patterning
- Ist Teil von
- Nature, 2007-01, Vol.445 (7125), p.311-314
- Ort / Verlag
- London: Nature Publishing
- Erscheinungsjahr
- 2007
- Quelle
- Psychology & Behavioral Sciences Collection
- Beschreibungen/Notizen
- The genetic mechanisms regulating tetrapod limb development are well characterized, but how they were assembled during evolution and their function in basal vertebrates is poorly understood. Initial studies report that chondrichthyans, the most primitive extant vertebrates with paired appendages, differ from ray-finned fish and tetrapods in having Sonic hedgehog (Shh)-independent patterning of the appendage skeleton. Here we demonstrate that chondrichthyans share patterns of appendage Shh expression, Shh appendage-specific regulatory DNA, and Shh function with ray-finned fish and tetrapods. These studies demonstrate that some aspects of Shh function are deeply conserved in vertebrate phylogeny, but also highlight how the evolution of Shh regulation may underlie major morphological changes during appendage evolution.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0028-0836eISSN: 1476-4687, 1476-4679DOI: 10.1038/nature05436Titel-ID: cdi_proquest_miscellaneous_68927137
- Format
- –
- Schlagworte
- Animals, Biological and medical sciences, Biological Evolution, Body Patterning - drug effects, Chondrichthyes, Deoxyribonucleic acid, DNA, Dose-Response Relationship, Drug, Elasmobranchii - anatomy & histology, Elasmobranchii - embryology, Elasmobranchii - genetics, Elasmobranchii - metabolism, Evolution, Molecular, Evolutionary biology, Extremities - anatomy & histology, Extremities - embryology, Extremities - physiology, Fundamental and applied biological sciences. Psychology, Gene expression, Gene Expression Regulation, Developmental - drug effects, Genetics, Genetics of eukaryotes. Biological and molecular evolution, Hedgehog Proteins - genetics, Hedgehog Proteins - metabolism, Marine, Molecular Sequence Data, Skates (Fish) - anatomy & histology, Skates (Fish) - embryology, Skates (Fish) - genetics, Skates (Fish) - metabolism, Tretinoin - metabolism, Tretinoin - pharmacology, Vertebrates