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Type-2 cells as link between glial and neuronal lineage in adult hippocampal neurogenesis
Glia, 2006-12, Vol.54 (8), p.805-814
Steiner, Barbara
Klempin, Friederike
Wang, Liping
Kott, Monika
Kettenmann, Helmut
Kempermann, Gerd
2006
Details
Autor(en) / Beteiligte
Steiner, Barbara
Klempin, Friederike
Wang, Liping
Kott, Monika
Kettenmann, Helmut
Kempermann, Gerd
Titel
Type-2 cells as link between glial and neuronal lineage in adult hippocampal neurogenesis
Ist Teil von
Glia, 2006-12, Vol.54 (8), p.805-814
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2006
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
In the course of adult hippocampal neurogenesis, new cells go through a series of stages associated with proliferative activity. The most highly proliferative cell type is an intermediate precursor cell, called type‐2 cell. We here report that on the level of type‐2 cells a transition takes place between features associated with the glial and the neuronal lineage. We show that stem‐cell marker Sox2 and radial glia marker BLBP are expressed in type‐2 cells but label only a small percentage of the proliferating cells. By and large, precursor cell marker Sox2 was found to be widely expressed in hippocampal astrocytes. Between 3 h and 1 week after a single injection of permanent S‐phase marker bromodeoxyuridine (BrdU), the number of BrdU‐labeled BLBP‐positive cells did not change, consistent with the idea that both markers here are associated with the maintained precursor cell pool. Using reporter gene mice expressing the green fluorescent protein (GFP) under the promoter for nestin we found an overlap of GFP with markers of the neuronal lineage, doublecortin (DCX) and transcription factor NeuroD1 in type‐2 cells, whereas in glial fibrillary acidic protein (GFAP)‐GFP mice expression of GFP and NeuroD1 or DCX was mutually exclusive. Electrophysiologically, the group of type‐2 cells fell into two subgroups: one with astrocytic properties and another with an early “complex” phenotype of neural progenitor cells. Our data further support the existence of proliferative precursor cells that mark the transition between glia‐like states and neuronal differentiation. © 2006 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0894-1491
eISSN: 1098-1136
DOI: 10.1002/glia.20407
Titel-ID: cdi_proquest_miscellaneous_68918232
Format
–
Schlagworte
Animals
,
Basic Helix-Loop-Helix Transcription Factors - metabolism
,
Biological and medical sciences
,
Biomarkers - metabolism
,
BLBP
,
Bromodeoxyuridine
,
Cell Differentiation - physiology
,
Cell Lineage - physiology
,
Cell Proliferation
,
dentate gyrus
,
DNA-Binding Proteins - metabolism
,
Fatty Acid-Binding Protein 7
,
Fatty Acid-Binding Proteins - metabolism
,
Female
,
Fundamental and applied biological sciences. Psychology
,
Glial Fibrillary Acidic Protein - metabolism
,
Green Fluorescent Proteins
,
Hippocampus - cytology
,
Hippocampus - physiology
,
Isolated neuron and nerve. Neuroglia
,
Mice
,
Mice, Transgenic
,
Microtubule-Associated Proteins - metabolism
,
Nerve Tissue Proteins - metabolism
,
Neurons - cytology
,
Neurons - physiology
,
Neuropeptides - metabolism
,
precursor cells
,
radial glia
,
Sox2
,
SOXB1 Transcription Factors
,
Stem Cells - cytology
,
Stem Cells - physiology
,
Trans-Activators - metabolism
,
Vertebrates: nervous system and sense organs
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