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Science (American Association for the Advancement of Science), 2005-12, Vol.310 (5755), p.1817-1821
2005
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Details

Autor(en) / Beteiligte
Titel
Widespread Impact of Mammalian MicroRNAs on mRNA Repression and Evolution
Ist Teil von
  • Science (American Association for the Advancement of Science), 2005-12, Vol.310 (5755), p.1817-1821
Ort / Verlag
Washington, DC: American Association for the Advancement of Science
Erscheinungsjahr
2005
Quelle
American Association for the Advancement of Science
Beschreibungen/Notizen
  • Thousands of mammalian messenger RNAs are under selective pressure to maintain 7-nucleotide sites matching microRNAs (miRNAs). We found that these conserved targets are often highly expressed at developmental stages before miRNA expression and that their levels tend to fall as the miRNA that targets them begins to accumulate. Nonconserved sites, which outnumber the conserved sites 10 to 1, also mediate repression. As a consequence, genes preferentially expressed at the same time and place as a miRNA have evolved to selectively avoid sites matching the miRNA. This phenomenon of selective avoidance extends to thousands of genes and enables spatial and temporal specificities of miRNAs to be revealed by finding tissues and developmental stages in which messages with corresponding sites are expressed at lower levels.

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