Details

Autor(en) / Beteiligte

• Jolly, Sanjit
• Newton, Gary
• Horlick, Eric
• Seidelin, Peter H.
• Ross, Heather J.
• Husain, Mansoor
• Dzavik, Vladimir

Titel

Effect of Vasopressin on Hemodynamics in Patients With Refractory Cardiogenic Shock Complicating Acute Myocardial Infarction

Ist Teil von

• The American journal of cardiology, 2005-12, Vol.96 (12), p.1617-1620

Ort / Verlag

New York, NY: Elsevier Inc

Erscheinungsjahr

2005

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• In a retrospective study of 36 patients who developed cardiogenic shock after myocardial infarction, intravenous vasopressin therapy increased mean arterial pressure from 56 to 73 mm Hg at 1 hour (p <0.001) and maintained it for 24 hours without changing pulmonary capillary wedge pressure, cardiac index, urine output, or other inotropic requirements. After norepinephrine administration, mean pulmonary capillary wedge pressure increased at 1 hour from 21 to 24 mm Hg (p = 0.04); however, this increase was not sustained at 12 and 24 hours. Norepinephrine was associated with a significant increase in cardiac power index at 24 hours, whereas there was only a trend for an increase in cardiac power with vasopressin therapy. In a cohort of patients who developed refractory cardiogenic shock after myocardial infarction, vasopressin was associated with increased mean arterial pressure and no adverse effect on other hemodynamic parameters.