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High and persistent excretion of hepatitis A virus in immunocompetent patients
Journal of medical virology, 2006-11, Vol.78 (11), p.1398-1405
Tjon, Grace M.S.
Coutinho, Roel A.
van den Hoek, Anneke
Esman, Sylvia
Wijkmans, Clementine J.
Hoebe, Christian J.P.A.
Wolters, Bert
Swaan, Corien
Geskus, Ronald B.
Dukers, Nicole
Bruisten, Sylvia M.
2006
Details
Autor(en) / Beteiligte
Tjon, Grace M.S.
Coutinho, Roel A.
van den Hoek, Anneke
Esman, Sylvia
Wijkmans, Clementine J.
Hoebe, Christian J.P.A.
Wolters, Bert
Swaan, Corien
Geskus, Ronald B.
Dukers, Nicole
Bruisten, Sylvia M.
Titel
High and persistent excretion of hepatitis A virus in immunocompetent patients
Ist Teil von
Journal of medical virology, 2006-11, Vol.78 (11), p.1398-1405
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2006
Link zum Volltext
Quelle
Wiley Blackwell Single Titles
Beschreibungen/Notizen
The duration and level of virus excretion in blood and faeces of patients with hepatitis A virus (HAV) infection were studied in relation to levels of alanine aminotransferase (ALT), disease severity and HAV genotype. Clinical data, blood and faeces were collected from 27 patients with acute hepatitis A (median age: 33 years) for a maximum of 26 weeks. Single blood donations from 55 other patients with acute HAV (median age: 32 years) were also used. Virus loads were quantified by competitive nested RT‐PCR. HAV was excreted in faeces for a median period of 81 days after disease onset, with 50% of patients still excreting high levels at Day 36 (2 × 106–2 × 108 copies/ml faeces suspension). Viraemia was detected, but not quantifiable, for a median period of 42 days. In the first 10 days of illness, higher ALT levels were correlated with higher viraemia levels. Comparison of patients infected with genotype 1a with those infected with type 1b did not differ significantly in terms of the duration of HAV excretion or jaundice. In conclusion, faecal excretion of HAV is at a high titre in the first month, perhaps making patients infectious for a longer period than assumed currently. Blood banks should be aware that viraemia may be present for more than 1 month, and genotype did not affect the duration of virus excretion or jaundice. J. Med. Virol. 78:1398–1405, 2006. © 2006 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0146-6615
eISSN: 1096-9071
DOI: 10.1002/jmv.20711
Titel-ID: cdi_proquest_miscellaneous_68900837
Format
–
Schlagworte
Adolescent
,
Adult
,
Biological and medical sciences
,
Child
,
Feces - virology
,
Female
,
Fundamental and applied biological sciences. Psychology
,
HAV excretion
,
HAV levels
,
HAV viraemia
,
Hepatitis A - genetics
,
Hepatitis A - immunology
,
Hepatitis A - virology
,
Hepatitis A virus
,
Hepatitis A virus - physiology
,
Human viral diseases
,
Humans
,
Immunocompetence
,
Infectious diseases
,
Male
,
Medical sciences
,
Microbiology
,
Miscellaneous
,
Time Factors
,
Viral diseases
,
Viral Load
,
Virology
,
Virus Shedding - physiology
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