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Angiosarcoma of the breast
Cancer, 2005-12, Vol.104 (12), p.2682-2688
Vorburger, Stephan A.
Xing, Yan
Hunt, Kelly K.
Lakin, Gregory E.
Benjamin, Robert S.
Feig, Barry W.
Pisters, Peter W. T.
Ballo, Matthew T.
Chen, Lei
Trent, Jonathan
Burgess, Michael
Patel, Shreyaskumar
Pollock, Raphael E.
Cormier, Janice N.
2005
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Vorburger, Stephan A.
Xing, Yan
Hunt, Kelly K.
Lakin, Gregory E.
Benjamin, Robert S.
Feig, Barry W.
Pisters, Peter W. T.
Ballo, Matthew T.
Chen, Lei
Trent, Jonathan
Burgess, Michael
Patel, Shreyaskumar
Pollock, Raphael E.
Cormier, Janice N.
Titel
Angiosarcoma of the breast
Ist Teil von
Cancer, 2005-12, Vol.104 (12), p.2682-2688
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2005
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
BACKGROUND Angiosarcoma of the breast is a rare entity. The objectives of this study were to evaluate prognostic factors and determine outcomes in a large contemporary series of patients. METHODS Clinical and pathologic factors were analyzed in all patients with angiosarcoma of the breast treated between 1990 and 2003. Overall survival (OS) and disease‐free survival (DFS) were estimated using the methods of Kaplan and Meier. Multivariate analyses were performed to evaluate prognostic factors. RESULTS Fifty‐five women with angiosarcoma of the breast were identified. The median age was 49.1 years, and the median follow‐up time was 3.7 years. The median OS and DFS were 2.96 years and 2.26 years, respectively. For the 32 patients with primary angiosarcoma of the breast 5‐year OS was 59%. Twenty‐three (42%) patients had received prior radiation therapy for the treatment of breast cancer. These patients with radiation therapy‐associated angiosarcoma were on average 30 years older and less likely to present with distant metastatic disease than patients presenting with radiation‐naive angiosarcoma of the breast. Although radiation‐naive patients appeared to have had better early DFS and OS, the Kaplan–Meier curves were not statistically different between patients with radiation therapy‐associated disease and radiation therapy‐naive patients. On multivariate analysis, tumor recurrence (P = 0.006) was the only significant adverse prognostic factor noted for OS. CONCLUSIONS In this series of 55 patients with angiosarcoma of the breast, radiation therapy‐naive angiosarcomas occurred in younger patients, but they behaved similarly to radiation therapy‐associated angiosarcomas. Cancer 2005. © 2005 American Cancer Society. Angiosarcoma of the breast is a rare clinical entity that can occur sporadically or after radiation therapy. The 5‐year overall survival rate for all patients is 38%.
Sprache
Englisch
Identifikatoren
ISSN: 0008-543X
eISSN: 1097-0142
DOI: 10.1002/cncr.21531
Titel-ID: cdi_proquest_miscellaneous_68895197
Format
–
Schlagworte
Adult
,
angiosarcoma
,
Biological and medical sciences
,
Biopsy, Needle
,
breast cancer
,
Breast Neoplasms - mortality
,
Breast Neoplasms - pathology
,
Breast Neoplasms - therapy
,
Chemotherapy, Adjuvant
,
Cohort Studies
,
Combined Modality Therapy
,
Confidence Intervals
,
Disease-Free Survival
,
Female
,
Gynecology. Andrology. Obstetrics
,
Hemangiosarcoma - mortality
,
Hemangiosarcoma - pathology
,
Hemangiosarcoma - therapy
,
Humans
,
Immunohistochemistry
,
Mammary gland diseases
,
Mastectomy - methods
,
Medical sciences
,
Middle Aged
,
Neoplasm Staging
,
Probability
,
Prognosis
,
Proportional Hazards Models
,
radiation‐associated sarcoma
,
Radiotherapy, Adjuvant
,
Retrospective Studies
,
Risk Assessment
,
Survival Analysis
,
Tumors
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