Angewandte Chemie (International ed.), 2005-12, Vol.44 (48), p.7887-7891
2005
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Coumarinylmethyl Esters for Ultrafast Release of High Concentrations of Cyclic Nucleotides upon One- and Two-Photon Photolysis
- Ist Teil von
- Angewandte Chemie (International ed.), 2005-12, Vol.44 (48), p.7887-7891
- Ort / Verlag
- Weinheim: WILEY-VCH Verlag
- Erscheinungsjahr
- 2005
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Shedding light: Efficient activation of cyclic nucleoside monophosphates (cNMPs) can be achieved upon one‐ and two‐photon flash photolysis of novel photolabile coumarinylmethyl esters of cAMP and cGMP (A=adenosine, G=guanosine) as well as their 8‐bromo‐substituted derivatives. The phototriggers show high solubility in water and permit space‐ and time‐resolved investigations of the molecular mechanisms of cyclic nucleotide dependent processes.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1433-7851eISSN: 1521-3773DOI: 10.1002/anie.200502411Titel-ID: cdi_proquest_miscellaneous_68891168
- Format
- –
- Schlagworte
- Animals, Cell Line, Coumarins - chemical synthesis, Coumarins - chemistry, Cyclic Nucleotide-Gated Cation Channels, Esters - chemistry, Humans, ion channels, Ion Channels - genetics, Ion Channels - metabolism, Molecular Structure, nucleotides, Nucleotides, Cyclic - chemistry, Oocytes - metabolism, Patch-Clamp Techniques, photoactivatable compounds, Photolysis, Photons, signal transduction, Time Factors, Xenopus