The American journal of clinical nutrition, 2005-12, Vol.82 (6), p.1235-1243
2005
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Details
- Autor(en) / Beteiligte
- Titel
- Recombinant human growth hormone improves muscle amino acid uptake and whole-body protein metabolism in chronic hemodialysis patients
- Ist Teil von
- The American journal of clinical nutrition, 2005-12, Vol.82 (6), p.1235-1243
- Ort / Verlag
- Bethesda, MD: American Society for Clinical Nutrition
- Erscheinungsjahr
- 2005
- Quelle
- Oxford Journals 2020 Medicine
- Beschreibungen/Notizen
- BACKGROUND: Intradialytic parenteral nutrition (IDPN), with or without exercise, has been shown to reverse the net negative whole-body and forearm muscle protein balances observed during hemodialysis. Pharmacologic doses of recombinant human growth hormone (rhGH) constitute another potential anabolic therapy in chronic hemodialysis patients. OBJECTIVE: Our goal was to examine the potential additive anabolic effects of rhGH compared with IDPN and exercise on protein and energy homeostasis. DESIGN: We studied 7 chronic hemodialysis patients in a crossover design study in which each subject participated in 2 protocols: GH (rhGH + IDPN + exercise) and no GH (IDPN + exercise). During the GH protocol, the subjects were studied after 3 daily doses of rhGH. Each subject was studied 2 h before, 4 h during, and 2 h after a hemodialysis session with the use of a primed, constant infusion of L-[1-¹³C]leucine. RESULTS: Whole-body net protein balance was -0.50 ± 0.07 mg · kg fat-free mass⁻¹ · min⁻¹ when the patients did not receive rhGH and -0.39 ± 0.04 mg · kg fat-free mass⁻¹ · min⁻¹ when the patients received rhGH, a 22% improvement in prehemodialysis whole-body protein homeostasis (P < 0.05). Essential amino acid muscle loss was also significantly less during the prehemodialysis period when rhGH was administered (-18 ± 23 compared with -71 ± 20 mmol/L; P < 0.05). The whole-body anabolic effects of rhGH observed during the prehemodialysis period persisted throughout the entire study, as evidenced by a lack of significant interaction or main effect of treatment during hemodialysis and in the posthemodialysis period. CONCLUSION: rhGH improves whole-body protein homeostasis in chronic hemodialysis patients.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0002-9165eISSN: 1938-3207DOI: 10.1093/ajcn/82.6.1235Titel-ID: cdi_proquest_miscellaneous_68872435
- Format
- –
- Schlagworte
- Adult, Amino Acids - blood, Amino Acids - metabolism, anabolic therapy, Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy, Biological and medical sciences, Carbon Isotopes, chronic diseases, Clinical trials, Cross-Over Studies, Emergency and intensive care: renal failure. Dialysis management, Energy, energy balance, Energy Metabolism - drug effects, Energy Metabolism - physiology, Exercise, Exercise - physiology, Female, Growth hormones, Hemodialysis, homeostasis, Hormones. Endocrine system, Human Growth Hormone - pharmacology, Humans, Intensive care medicine, kidney diseases, Kidney Failure, Chronic - metabolism, Kidney Failure, Chronic - therapy, Male, Medical sciences, muscle contraction, muscle net protein homeostasis, muscle protein, muscle protein balances, Muscle, Skeletal - metabolism, nutrient partitioning, Oxidation-Reduction, Oxygen Consumption - drug effects, Oxygen Consumption - physiology, Parenteral Nutrition, patients, Pharmacology. Drug treatments, protein metabolism, protein transport, Proteins, Proteins - metabolism, recombinant fusion proteins, Recombinant Proteins - pharmacology, Renal Dialysis - adverse effects, skeletal muscle, somatotropin, total parenteral nutrition, Treatment Outcome