Zhong hua yi xue za zhi, 2005-11, Vol.85 (43), p.3039-3042
2005
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- Autor(en) / Beteiligte
- Titel
- Treatment of rabbits bearing advanced VX2 tumors in the mammary gland with nano-sized liposomal adriamycin administered by various routes
- Ist Teil von
- Zhong hua yi xue za zhi, 2005-11, Vol.85 (43), p.3039-3042
- Ort / Verlag
- China
- Erscheinungsjahr
- 2005
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To investigate the therapeutic effect of nano-sized liposomal adriamycin (NLADR) administered by various routes on rabbits bearing advanced breast tumors. NLADR with a mean diameter of 120 nm was prepared by pH gradient-driven drug encapsulation method. VX(2) tumor mass suspension was injected into the breast tissues of 50 female New Zealand White rabbits. Six weeks after the inoculation 38 surviving tumor-bearing rabbits were randomly divided into 5 groups: group A (control group), receiving a sham treatment; group B, receiving subcutaneous injection of NLADR with a dose of 1 mg/kg into the areas adjacent to the implanted tumor; group C, receiving intravenous injection of NLADR with a dose of 1 mg/kg; group D, receiving NLADR with a dose of 1 mg/kg administered by subcutaneous injection combined with intravenous injection with half of the whole dose for both routes; and group E, receiving intravenous injection of free adriamycin (FADR). The treatment was repeated every 48 hours. The rabbits were killed 48 ho
- Sprache
- Chinesisch
- Identifikatoren
- ISSN: 0376-2491Titel-ID: cdi_proquest_miscellaneous_68872214
- Format
- –
- Schlagworte
- Animals, Antibiotics, Antineoplastic - administration & dosage, Antibiotics, Antineoplastic - pharmacology, Antibiotics, Antineoplastic - therapeutic use, Apoptosis - drug effects, Doxorubicin - administration & dosage, Doxorubicin - pharmacology, Doxorubicin - therapeutic use, Female, Gene Expression Regulation, Neoplastic - drug effects, Injections, Intravenous, Injections, Subcutaneous, Liposomes, Mammary Neoplasms, Experimental - drug therapy, Mammary Neoplasms, Experimental - genetics, Mammary Neoplasms, Experimental - pathology, Nanoparticles, Proliferating Cell Nuclear Antigen - genetics, Rabbits, Random Allocation, Reverse Transcriptase Polymerase Chain Reaction, RNA, Messenger - genetics, RNA, Messenger - metabolism