Clinical cancer research, 2005-12, Vol.11 (23), p.8326-8331
2005
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- Autor(en) / Beteiligte
- Titel
- The Expression of the Regulatory T Cell–Specific Forkhead Box Transcription Factor FoxP3 Is Associated with Poor Prognosis in Ovarian Cancer
- Ist Teil von
- Clinical cancer research, 2005-12, Vol.11 (23), p.8326-8331
- Ort / Verlag
- United States: American Association for Cancer Research
- Erscheinungsjahr
- 2005
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Purpose: The forkhead box transcription factor FoxP3 is specifically expressed in T cells with regulatory properties (Treg). Recently, high numbers of Treg were described to be associated with poor survival in different malignancies. The aim of the presented study was determine the prognostic effect of FoxP3 mRNA expression (reflecting the tissue content of Treg) in ovarian carcinoma and its relation with cytokines, such as IFN-γ. Experimental Design: Total RNA was isolated from 99 ovarian carcinoma and from 14 healthy ovarian biopsies. Real-time PCR for FoxP3 was done and correlated with IFN-γ-, CD3-, IRF-1-, SOCS-1-, HER-2-, and iNOS expression as well as patients' outcome. The mRNA data was corroborated by FoxP3 immunohistochemistry. Results: Quantitation of FoxP3 expression identified a patient subgroup (>81th percentile), which is characterized by a significantly worse prognosis in terms of overall survival (27.8 versus 77.3 months, P = 0.0034) and progression-free survival (18 versus 57.5 months; P = 0.0041). FoxP3 expression correlated with IFN-γ, IRF-1, and CD3 expression. High FoxP3 expression represents an independent prognostic factor for overall survival ( P = 0.004) and progression-free survival ( P = 0.004). Conclusions: High expression levels of FoxP3 might represent a surrogate marker for an immunosuppressive milieu contributing to tumor immune escape. Strategies selectively depleting Treg might improve the antitumor activity of endogenously arising tumor-reactive T cells and immunotherapies using vaccines or antibodies.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1078-0432eISSN: 1557-3265DOI: 10.1158/1078-0432.CCR-05-1244Titel-ID: cdi_proquest_miscellaneous_68849315
- Format
- –
- Schlagworte
- Adenocarcinoma, Mucinous - genetics, Adenocarcinoma, Mucinous - immunology, Adenocarcinoma, Mucinous - pathology, Aged, Biomarkers, Tumor - genetics, Biomarkers, Tumor - metabolism, Case-Control Studies, CD3 Complex - genetics, CD3 Complex - metabolism, Cystadenocarcinoma, Serous - genetics, Cystadenocarcinoma, Serous - immunology, Cystadenocarcinoma, Serous - pathology, Female, Forkhead Transcription Factors - genetics, Forkhead Transcription Factors - metabolism, FoxP3, Humans, Interferon Regulatory Factor-1 - genetics, Interferon Regulatory Factor-1 - metabolism, Interferon-gamma - genetics, Interferon-gamma - metabolism, Intracellular Signaling Peptides and Proteins - genetics, Intracellular Signaling Peptides and Proteins - metabolism, Middle Aged, Neoplasm Staging, Nitric Oxide Synthase Type II - genetics, Nitric Oxide Synthase Type II - metabolism, Ovarian cancer, Ovarian Neoplasms - genetics, Ovarian Neoplasms - immunology, Ovarian Neoplasms - pathology, Prognosis, Receptor, ErbB-2 - genetics, Receptor, ErbB-2 - metabolism, Regulatory T cells, Repressor Proteins - genetics, Repressor Proteins - metabolism, Reverse Transcriptase Polymerase Chain Reaction, RNA, Messenger - metabolism, Suppressor of Cytokine Signaling 1 Protein, Suppressor of Cytokine Signaling Proteins - genetics, Suppressor of Cytokine Signaling Proteins - metabolism, Survival Rate, T-Lymphocytes, Regulatory - immunology