Trends in genetics, 2005-12, Vol.21 (12), p.655-663
2005
Details
- Autor(en) / Beteiligte
- Titel
- Origin, evolution and genetic effects of nuclear insertions of organelle DNA
- Ist Teil von
- Trends in genetics, 2005-12, Vol.21 (12), p.655-663
- Ort / Verlag
- Oxford: Elsevier Ltd
- Erscheinungsjahr
- 2005
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- In eukaryotes, nuclear genomes are subject to an influx of DNA from mitochondria and plastids. The nuclear insertion of organellar sequences can occur during the illegitimate repair of double-stranded breaks. After integration, nuclear organelle DNA is modified by point mutations, and by deletions. Insertion of organelle DNA into nuclear genes is not rare and can potentially have harmful effects. In humans, some insertions of nuclear mitochondrial DNA are associated with heritable diseases. It remains to be determined whether nuclear organelle DNA can contribute beneficially to gene evolution.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0168-9525DOI: 10.1016/j.tig.2005.09.004Titel-ID: cdi_proquest_miscellaneous_68807772
- Format
- –
- Schlagworte
- Biological and medical sciences, Cell Nucleus - genetics, Cell Nucleus - metabolism, Chloroplasts - genetics, Chloroplasts - metabolism, DNA - genetics, DNA - metabolism, Evolution, Molecular, Fundamental and applied biological sciences. Psychology, Genetics of eukaryotes. Biological and molecular evolution, Humans, Mitochondria - genetics, Mitochondria - metabolism, Molecular and cellular biology, Phylogeny, Plants - genetics, Plants - metabolism