Details

Autor(en) / Beteiligte

• Bartoli, Giuseppe
• Bosco, Marcella
• Carlone, Armando
• Cavalli, Andrea
• Locatelli, Manuela
• Mazzanti, Andrea
• Ricci, Paolo
• Sambri, Letizia
• Melchiorre, Paolo

Titel

Organocatalytic Asymmetric Conjugate Addition of 1,3-Dicarbonyl Compounds to Maleimides

Ist Teil von

• Angewandte Chemie (International ed.), 2006-07, Vol.45 (30), p.4966-4970

Ort / Verlag

Weinheim: WILEY-VCH Verlag

Erscheinungsjahr

2006

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Nature, our teacher! The natural alkaloids quinine (Q) and quinidine (QD) serve as efficient bifunctional organocatalysts in the asymmetric conjugate addition of 1,3‐dicarbonyl compounds to maleimides (see scheme). Very high selectivity is observed in this one‐step construction of highly functionalized compounds with two adjacent stereogenic centers from commercially available precursors. R1,R3=alkyl, aryl, O‐alkyl; R2=alkyl, Bn; R4=Bn.