Seminars in Immunology, 2006-10, Vol.18 (5), p.318-326
2006
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- BLyS and B cell homeostasis
- Ist Teil von
- Seminars in Immunology, 2006-10, Vol.18 (5), p.318-326
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2006
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- Naïve peripheral B cells survive in vivo because of active stimulation by the TNF superfamily ligand B lymphocyte stimulator (BLyS/BAFF). Although the survival promoting properties of BLyS are well known, the signal pathways and molecular effectors that characterize this stimulation are still being elucidated. In this communication, we discuss the signal cascades that effect BLyS dependent survival and the regulation of BLyS induced signaling. We also examine the role of BLyS as a growth factor and propose that BLyS induced metabolic enhancement optimizes the B cell response to BCR and TLR-dependent signaling.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1044-5323eISSN: 1096-3618, 1365-2567DOI: 10.1016/j.smim.2006.06.001Titel-ID: cdi_proquest_miscellaneous_68792531
- Format
- –
- Schlagworte
- Akt, Alternative Splicing, Animals, Apoptosis, B cells, B-Cell Activating Factor - immunology, B-Cell Activating Factor - physiology, B-Cell Activation Factor Receptor - immunology, B-Cell Activation Factor Receptor - physiology, B-Cell Maturation Antigen - immunology, B-Cell Maturation Antigen - physiology, B-Lymphocyte Subsets - cytology, B-Lymphocyte Subsets - immunology, Cell Survival, Growth factor, Homeostasis, Humans, Immunoglobulin Class Switching, Lymphoma, B-Cell - immunology, Lymphoma, B-Cell - pathology, Mcl-2, Mice, Mice, Inbred A, Models, Immunological, Neoplasm Proteins - immunology, Neoplasm Proteins - physiology, Pim, Protein Kinases - physiology, Recombinant Fusion Proteins - physiology, Signal Transduction, Survival, Transcription Factors - physiology, Transfection, Transmembrane Activator and CAML Interactor Protein - immunology, Transmembrane Activator and CAML Interactor Protein - physiology, Tumor Necrosis Factor Ligand Superfamily Member 13 - immunology, Tumor Necrosis Factor Ligand Superfamily Member 13 - physiology