UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 8 von 20
Datensatz exportieren als...
BibTeX
Netrin/DCC-mediated attraction of vagal sensory axons to the fetal mouse gut
Journal of comparative neurology (1911), 2006-10, Vol.498 (5), p.567-580
Ratcliffe, Elyanne M.
Setru, Suhas U.
Chen, Jason J.
Li, Zhishan S.
D'Autréaux, Fabien
Gershon, Michael D.
2006
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Ratcliffe, Elyanne M.
Setru, Suhas U.
Chen, Jason J.
Li, Zhishan S.
D'Autréaux, Fabien
Gershon, Michael D.
Titel
Netrin/DCC-mediated attraction of vagal sensory axons to the fetal mouse gut
Ist Teil von
Journal of comparative neurology (1911), 2006-10, Vol.498 (5), p.567-580
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2006
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
Vagal sensory axons and migrating neural crest‐derived precursor cells follow similar pathways to reach the gut. The crest‐derived cells express the netrin receptor deleted in colorectal cancer (DCC) and migrate toward netrins expressed by the intestinal mucosa and pancreas; this attraction is required for the formation of submucosal and pancreatic ganglia. We tested the hypothesis that enteric netrins also attract vagal sensory fibers. These axons were located as a function of age in fetal mice by applying the lipophilic tracer 1,1′‐dioctadecyl‐3,3,3′,3′‐tetramethylindocarbocyanine perchlorate (DiI) bilaterally to nodose ganglia. DiI‐labeled axons were found in the esophagus and proximal stomach by E12 and, more distally, in the small bowel at E14–E16. Transcripts encoding DCC were expressed in the nodose ganglia of mice from E12 to adulthood but were developmentally regulated. Paraesophageal anterior and posterior vagal trunks were DCC immunoreactive from E12 to E16. Transcripts encoding netrin‐1 were expressed in the developing foregut and midgut; netrin‐1 immunoreactivity was detected in the outer gut mesenchyme and mucosal epithelium. Neurites from explanted E14 nodose ganglia grew selectively toward cocultured E14 distal foregut explants (P < 0.01). Antibodies to DCC specifically abolished this preferential outgrowth (P < 0.05). Nodose axons also grew selectively toward cocultured netrin‐secreting 293‐EBNA cells (P < 0.005); antibodies to DCC again blocked this preferential outgrowth (P < 0.05). These data suggest that netrins, which are expressed in the bowel, attract DCC‐expressing vagal sensory axons. J. Comp. Neurol. 498:567–580, 2006. © 2006 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0021-9967
eISSN: 1096-9861
DOI: 10.1002/cne.21027
Titel-ID: cdi_proquest_miscellaneous_68773529
Format
–
Schlagworte
Age Factors
,
Animals
,
Animals, Newborn
,
Axons - physiology
,
Carbocyanines - metabolism
,
Cell Movement - physiology
,
DCC Receptor
,
development
,
Embryo, Mammalian
,
enteric nervous system
,
Female
,
gastrointestinal tract
,
Gastrointestinal Tract - embryology
,
Gastrointestinal Tract - innervation
,
Gastrointestinal Tract - metabolism
,
Gene Expression Regulation, Developmental - physiology
,
guidance molecules
,
Histocytochemistry - methods
,
Male
,
Mice
,
Nerve Growth Factors - genetics
,
Nerve Growth Factors - physiology
,
Netrin-1
,
Neurites - physiology
,
Neurons, Afferent - physiology
,
nodose ganglia
,
Nodose Ganglion - cytology
,
Nodose Ganglion - metabolism
,
Organ Culture Techniques
,
Pregnancy
,
Receptors, Cell Surface - genetics
,
Receptors, Cell Surface - physiology
,
Reverse Transcriptase Polymerase Chain Reaction - methods
,
RNA, Messenger - genetics
,
RNA, Messenger - metabolism
,
Tumor Suppressor Proteins - genetics
,
Tumor Suppressor Proteins - physiology
,
Ubiquitin Thiolesterase - metabolism
,
vagus nerve
,
Vagus Nerve - cytology
,
Vagus Nerve - physiology
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX