Journal of organic chemistry, 2005-11, Vol.70 (23), p.9093-9102
2005
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Details
- Autor(en) / Beteiligte
- Titel
- DNA Cleavage by the Photolysis of Cyclopentadienyl Metal Complexes: Mechanistic Studies and Sequence Selectivity of Strand Scission by CpW(CO)3CH3
- Ist Teil von
- Journal of organic chemistry, 2005-11, Vol.70 (23), p.9093-9102
- Ort / Verlag
- Washington, DC: American Chemical Society
- Erscheinungsjahr
- 2005
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The photolysis of CpW(CO)3Me has been shown to produce methyl radicals and to cleave DNA in a single-stranded manner, and preliminary evidence implicated a carbon-centered radical in this process. In this work, the mechanism of strand scission in this reaction was determined to occur by hydrogen atom abstraction from the 4‘- and 5‘-positions of the deoxyribose moiety of the backbone of DNA. Additionally, in a side reaction that does not lead to frank strand scission, all four bases of DNA are methylated under these conditions; however, none of these base or backbone modifications lead to the formation of abasic sites.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0022-3263eISSN: 1520-6904DOI: 10.1021/jo050338hTitel-ID: cdi_proquest_miscellaneous_68766797
- Format
- –
- Schlagworte
- Analytical, structural and metabolic biochemistry, Biological and medical sciences, Chemistry, Coordination compounds, Cyclopentanes - chemistry, Deoxyribose - chemistry, Deoxyribose - metabolism, DNA - chemistry, DNA - radiation effects, DNA Methylation, Dna, deoxyribonucleoproteins, Electron Spin Resonance Spectroscopy, Exact sciences and technology, Fundamental and applied biological sciences. Psychology, Inorganic chemistry and origins of life, Nucleic acids, Organometallic Compounds - chemistry, Photochemistry, Photolysis, Plasmids, Preparations and properties, Tungsten - chemistry