Bioorganic & medicinal chemistry letters, 2005-12, Vol.15 (24), p.5439-5441
2005
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Details
- Autor(en) / Beteiligte
- Titel
- Indole-2-carboxamidines as novel NR2B selective NMDA receptor antagonists
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2005-12, Vol.15 (24), p.5439-5441
- Ort / Verlag
- Oxford: Elsevier Ltd
- Erscheinungsjahr
- 2005
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- A novel series of indole-2-carboxamidines derivatives was prepared and identified as NR2B selective NMDA receptor antagonists. The influence of the substituents on the indole skeleton as well as the substitution of the benzyl moiety on the biological activity of the compounds was studied. Compound 5a was po active in the formalin test in mouse. A novel series of indole-2-carboxamidine derivatives was prepared and identified as NR2B selective NMDA receptor antagonists. The influence of the substituents on the indole skeleton as well as the substitution of the benzyl moiety on the biological activity of the compounds was studied. Compound 5a was po active in the formalin test in mouse.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/j.bmcl.2005.08.110Titel-ID: cdi_proquest_miscellaneous_68745335
- Format
- –
- Schlagworte
- Aminoimidazole Carboxamide - chemical synthesis, Aminoimidazole Carboxamide - pharmacology, Animals, Biological and medical sciences, Calcium - metabolism, Cell Culture Techniques, Cerebral Cortex - cytology, Cerebral Cortex - physiology, Glutamatergic system (aspartate and other excitatory aminoacids), Imidazoles - chemical synthesis, Imidazoles - pharmacology, Indole-2-carboxamidine, Indoles - chemical synthesis, Indoles - pharmacology, Medical sciences, N-Methylaspartate - pharmacology, NB2B, Neuropharmacology, Neurotransmitters. Neurotransmission. Receptors, NMDA, Pharmacology. Drug treatments, Rats, Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors