Details

Autor(en) / Beteiligte

• Kim, Dong-Chan
• Lee, So-Young
• Jun, Dong-Jae
• Kim, Sun-Hee
• Lee, Jong-Hee
• Hur, Eun-Mi
• Baek, Nam-In
• Kim, Kyong-Tai

Titel

Inhibition of store-operated calcium entry-mediated superoxide generation by histamine trifluoromethyltoluide independent of histamine receptors

Ist Teil von

• Biochemical pharmacology, 2005-11, Vol.70 (11), p.1613-1622

Ort / Verlag

New York, NY: Elsevier Inc

Erscheinungsjahr

2005

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Store-operated calcium entry (SOCE) plays an important role in shaping the Ca 2+ response of various tissues and cell types. In this report, we show that thapsigargin (TG)-induced SOCE was inhibited by the histamine receptor agonist, histamine-trifluoromethyltoluide (HTMT), in U937 and HL-60 human promyelocytes. Preincubation of HTMT resulted in a significant inhibition of subsequent TG-induced Ca 2+ elevation without affecting Ca 2+ release from intracellular stores. HTMT also inhibited TG-induced Ca 2+ current and Ba 2+/Mn 2+ influx in a concentration-dependent manner. In contrast with HTMT, other H1 histamine receptor agonists, histamine, 2-methylhistamine and 2-thiazolylethylamine, did not affect TG-induced SOCE. In addition, HTMT also attenuated TG-induced cytosolic superoxide generation. Taken together, our data clearly suggest that the anti-inflammatory effect of HTMT may occur through direct inhibition of SOCE.