Clinical infectious diseases, 2006-09, Vol.43 (Supplement-2), p.S49-S56
2006
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Details
- Autor(en) / Beteiligte
- Titel
- Mechanisms of Multidrug Resistance in Acinetobacter Species and Pseudomonas aeruginosa
- Ist Teil von
- Clinical infectious diseases, 2006-09, Vol.43 (Supplement-2), p.S49-S56
- Ort / Verlag
- United States: The University of Chicago Press
- Erscheinungsjahr
- 2006
- Quelle
- Oxford Journals 2020 Medicine
- Beschreibungen/Notizen
- Acinetobacter species and Pseudomonas aeruginosa are noted for their intrinsic resistance to antibiotics and for their ability to acquire genes encoding resistance determinants. Foremost among the mechanisms of resistance in both of these pathogens is the production of β-lactamases and aminoglycoside-modifying enzymes. Additionally, diminished expression of outer membrane proteins, mutations in topoisomerases, and up-regulation of efflux pumps play an important part in antibiotic resistance. Unfortunately, the accumulation of multiple mechanisms of resistance leads to the development of multiply resistant or even “panresistant” strains.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1058-4838eISSN: 1537-6591DOI: 10.1086/504477Titel-ID: cdi_proquest_miscellaneous_68721374
- Format
- –
- Schlagworte
- Acinetobacter, Acinetobacter - drug effects, Acinetobacter - enzymology, Acinetobacter - genetics, Acinetobacter baumannii, Aminoglycosides, Aminoglycosides - metabolism, Antibiotics, beta-Lactamases - genetics, beta-Lactamases - metabolism, Carbapenems, Cross Infection - drug therapy, Drug Resistance, Multiple, Bacterial - drug effects, Drug Resistance, Multiple, Bacterial - genetics, Enzymes, Genetic mutation, Humans, Infections, Membrane Transport Proteins - drug effects, Membrane Transport Proteins - genetics, Porins - drug effects, Porins - genetics, Pseudomonas aeruginosa, Pseudomonas aeruginosa - drug effects, Pseudomonas aeruginosa - enzymology, Pseudomonas aeruginosa - genetics, Pumps, Quinolones - pharmacology