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Axonal degeneration stimulates the formation of NG2+ cells and oligodendrocytes in the mouse
Glia, 2006-08, Vol.54 (2), p.105-115
Nielsen, Helle H.
Ladeby, Rune
Drøjdahl, Nina
Peterson, Alan C.
Finsen, Bente
2006
Details
Autor(en) / Beteiligte
Nielsen, Helle H.
Ladeby, Rune
Drøjdahl, Nina
Peterson, Alan C.
Finsen, Bente
Titel
Axonal degeneration stimulates the formation of NG2+ cells and oligodendrocytes in the mouse
Ist Teil von
Glia, 2006-08, Vol.54 (2), p.105-115
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2006
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
Proliferation of the adult NG2‐expressing oligodendrocyte precursor cells has traditionally been viewed as a remyelination response ensuing from destruction of myelin and oligodendrocytes, and not to the axonal pathology that is also a characteristic of demyelinating disease. To better understand the response of the NG2+ cells to the different components of demyelinating pathology, we investigated the response of adult NG2+ cells to axonal degeneration in the absence of primary myelin or oligodendrocyte pathology. Axonal degeneration was induced in the hippocampal dentate gyrus of adult mice by transection of the entorhino‐dentate perforant path projection. The acutely induced degeneration of axons and terminals resulted in a prompt response of NG2+ cells, consisting of morphological transformation, cellular proliferation, and upregulation of NG2 expression days 2–3 after surgery. This was followed by a reduction of cellular NG2 expression to subnormal levels from day 5 to 7 and reappearance of normal appearing NG2+ cells from day 10. Mice that had received repeated injections of bromodeoxyuridine from 24 to 72 h after surgery contained significant numbers of bromodeoxyuridine‐incorporating oligodendrocytes in the areas with axonal degeneration at day 7. The results suggest that axonal degeneration induces a unique sequence of changes of NG2+ cells and that a subpopulation of the newly generated NG2+ cells differentiate into oligodendrocytes. © 2006 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0894-1491
eISSN: 1098-1136
DOI: 10.1002/glia.20357
Titel-ID: cdi_proquest_miscellaneous_68717118
Format
–
Schlagworte
Animals
,
Antigens - biosynthesis
,
Antigens - genetics
,
Axons - metabolism
,
Axons - pathology
,
Biological and medical sciences
,
BrdU
,
Cell Differentiation - genetics
,
Cell Differentiation - physiology
,
Cell Proliferation
,
entorhinal cortex lesion
,
Fundamental and applied biological sciences. Psychology
,
hippocampus
,
Isolated neuron and nerve. Neuroglia
,
Male
,
MBP LacZ transgenic mice
,
Mice
,
Mice, Inbred C3H
,
Mice, Inbred C57BL
,
Mice, Transgenic
,
myelin
,
Nerve Degeneration - genetics
,
Nerve Degeneration - metabolism
,
Nerve Degeneration - pathology
,
Oligodendroglia - cytology
,
Oligodendroglia - metabolism
,
Proteoglycans - biosynthesis
,
Proteoglycans - genetics
,
Vertebrates: nervous system and sense organs
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