Details

Autor(en) / Beteiligte

• De Melo, Giany O.
• Malvar, David do C.
• Vanderlinde, Frederico A.
• Pires, Priscilla A.
• Côrtes, Wellington S.
• Filho, Pedro Germano
• Muzitano, Michelle F.
• Kaiser, Carlos R.
• Costa, Sônia S.

Titel

Phytochemical and pharmacological study of Sedum dendroideum leaf juice

Ist Teil von

• Journal of ethnopharmacology, 2005-11, Vol.102 (2), p.217-220

Ort / Verlag

Shannon: Elsevier Ireland Ltd

Erscheinungsjahr

2005

Quelle

MEDLINE

Beschreibungen/Notizen

• The fresh juice from leaves of Sedum dendroideum Moc & Sessé (Crassulaceae) is used in Brazilian traditional medicine for the treatment of gastric and inflammatory disorders. The present investigation was carried out to evaluate in vivo antinociceptive and anti-inflammatory activities of this plant material. The oral administration (0.1–1 g/kg) of the lyophilized Sedum dendroideum juice (LJ) caused a significant dose-related reduction of acetic acid-induced writhing response (ID 50 = 631 mg/kg) and inhibited croton oil-induced ear oedema formation (66% inhibition at 1 g/kg) in mice. In the formalin-induced nociception in mice, LJ (1 g/kg) only inhibited the second phase of nociception (46%). Phytochemical investigation revealed four known kaempferol glycosides, here, described at the first time for this species. These flavonoids probably explain the antinociceptive and anti-inflammatory effects of the fresh juice of Sedum dendroideum.