Bioorganic & medicinal chemistry letters, 2005-12, Vol.15 (23), p.5344-5352
2005
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Details
- Autor(en) / Beteiligte
- Titel
- Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2005-12, Vol.15 (23), p.5344-5352
- Ort / Verlag
- Oxford: Elsevier Ltd
- Erscheinungsjahr
- 2005
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- We describe the structure-based design and synthesis of nanomolar, orally bioavailable tissue factor/factor VIIa inhibitors which interfere with the coagulation cascade by selective inhibition of the extrinsic pathway. We describe the structure-based design and synthesis of highly potent, orally bioavailable tissue factor/factor VIIa inhibitors which interfere with the coagulation cascade by selective inhibition of the extrinsic pathway.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/j.bmcl.2005.04.079Titel-ID: cdi_proquest_miscellaneous_68709316
- Format
- –
- Schlagworte
- Administration, Oral, Animals, Anticoagulants - chemical synthesis, Anticoagulants - chemistry, Anticoagulants - pharmacology, Biological and medical sciences, Biological Availability, Blood. Blood coagulation. Reticuloendothelial system, Crystallography, X-Ray, Drug Design, Factor VIIa - antagonists & inhibitors, Glycine - analogs & derivatives, Glycine - chemistry, Humans, Medical sciences, Molecular Structure, Pharmacology. Drug treatments, Rats, Serine Proteinase Inhibitors - chemical synthesis, Serine Proteinase Inhibitors - chemistry, Serine Proteinase Inhibitors - pharmacology, Thromboplastin - antagonists & inhibitors