Muscle & nerve, 2005-11, Vol.32 (5), p.672-674
2005
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- Autor(en) / Beteiligte
- Titel
- A model of muscle atrophy using cast immobilization in mice
- Ist Teil von
- Muscle & nerve, 2005-11, Vol.32 (5), p.672-674
- Ort / Verlag
- Hoboken: Wiley Subscription Services, Inc., A Wiley Company
- Erscheinungsjahr
- 2005
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- We describe a new cast‐immobilization protocol to induce muscle atrophy in the lower hindlimb muscles of mice. Bilateral cast immobilization for 2 weeks in a shortened position resulted in a significant loss of muscle size and strength in the soleus and extensor digitorum longus. The availability of a model of cast immobilization in mice may benefit future studies targeting genetic or cell therapy interventions of muscle atrophy in transgenic and mutant mice strains. Muscle Nerve, 2005
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0148-639XeISSN: 1097-4598DOI: 10.1002/mus.20399Titel-ID: cdi_proquest_miscellaneous_68696038
- Format
- –
- Schlagworte
- Animals, Biological and medical sciences, cast immobilization, disuse atrophy, Female, Fundamental and applied biological sciences. Psychology, Hindlimb Suspension - adverse effects, Mice, Mice, Inbred C57BL, Models, Animal, muscle atrophy, Muscular Atrophy - etiology, Muscular Atrophy - physiopathology, Striated muscle. Tendons, Vertebrates: osteoarticular system, musculoskeletal system