UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 23 von 492
Datensatz exportieren als...
BibTeX
Retrospective analysis of case-control studies when the population is in Hardy-Weinberg equilibrium
Statistics in medicine, 2005-11, Vol.24 (21), p.3289-3310
Cheng, K. F.
Lin, W. J.
2005
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Cheng, K. F.
Lin, W. J.
Titel
Retrospective analysis of case-control studies when the population is in Hardy-Weinberg equilibrium
Ist Teil von
Statistics in medicine, 2005-11, Vol.24 (21), p.3289-3310
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2005
Quelle
Wiley Online Library All Journals
Beschreibungen/Notizen
Association analysis of genetic polymorphisms has been mostly performed in a case‐control setting in connection with the traditional logistic regression analysis. However, in a case‐control study, subjects are recruited according to their disease status and their past exposures are determined. Thus the natural model for making inference is the retrospective model. In this paper, we discuss some retrospective models and give maximum likelihood estimators of exposure effects and estimators of asymptotic variances, when the frequency distribution of exposures in controls contains information about the parameters of interest. Two situations about the control population are considered in this paper: (a) the control population or its subpopulations are in Hardy–Weinberg equilibrium; and (b) genetic and environmental factors are independent in the control population. Using the concept of asymptotic relative efficiency, we shall show the precision advantages of such retrospective analysis over the traditional prospective analysis. Maximum likelihood estimates and variance estimates under retrospective models are simple in computation and thus can be applied in many practical applications. We present one real example to illustrate our methods. Copyright © 2005 John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 0277-6715
eISSN: 1097-0258
DOI: 10.1002/sim.2190
Titel-ID: cdi_proquest_miscellaneous_68694662
Format
–
Schlagworte
Alcohol Dehydrogenase - genetics
,
Alcohol Drinking - adverse effects
,
Alleles
,
Case studies
,
Case-Control Studies
,
case-control study
,
Equilibrium
,
Genetics
,
Genetics, Population
,
Hardy-Weinberg equilibrium
,
Humans
,
Likelihood Functions
,
logistic regression
,
maximum likelihood estimate
,
Models, Genetic
,
Models, Statistical
,
Mouth Neoplasms - enzymology
,
Mouth Neoplasms - genetics
,
odds ratio
,
Polymorphism
,
retrospective model
,
Retrospective Studies
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX