Details

Autor(en) / Beteiligte

• Wong, Angela M.
• Patel, Nilay V.
• Patel, Nimesh K.
• Wei, Min
• Morgan, Todd E.
• de Beer, Maria C.
• de Villiers, Willem J.S.
• Finch, Caleb E.

Titel

Macrosialin increases during normal brain aging are attenuated by caloric restriction

Ist Teil von

• Neuroscience letters, 2005-12, Vol.390 (2), p.76-80

Ort / Verlag

Shannon: Elsevier Ireland Ltd

Erscheinungsjahr

2005

Quelle

MEDLINE

Beschreibungen/Notizen

• During normal aging, microglia develop an activated phenotype characterized by morphologic changes and induction of CD11b, MHC II, and other inflammatory markers. We show that macrosialin (CD68), a macrophage-specific protein, is increased by aging in selected brain regions of male C57BL/6NNia mice. In corpus callosum and striatum, macrosialin mRNA and protein increased ≥50% (24 months versus 4 months); hippocampus and cerebellum were unchanged. Caloric restriction (CR) attenuated these age-related increases. Since CR attenuates age-related increases in oxidative damage and inflammation, we examined whether oxidized lipoproteins and inflammatory processes regulate macrosialin using murine BV-2 microglial cells as a model. Oxidized low-density lipoproteins (oxLDL) induced macrosialin protein by 50%. Moreover, macrosialin was induced in response to lipopolysaccharide (LPS) plus interferon-γ (IFN-γ) which activates inflammatory pathways in BV-2 cells. Thus, the previously documented increase in oxidized lipoproteins, inflammation, and microglial activation during normal aging may contribute to the age-related increase in macrosialin expression.