Details
- Autor(en) / Beteiligte
- Titel
- Involvement of nuclear factor-kappaB in the inhibition of pro-inflammatory mediators by pinosylvin
- Ist Teil von
- Planta medica, 2006-07, Vol.72 (9), p.801-806
- Ort / Verlag
- Germany
- Erscheinungsjahr
- 2006
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Nuclear factor-kappaB (NF-kappaB) is a critical transcription factor for maximal expression of many of the cytokines that are involved in the pathogenesis of inflammatory diseases. In this study, we found that pinosylvin, a natural stilbenoid that is a component of the pine leaf (Pinus densiflora), significantly inhibited LPS-induced NF-kappaB activation in a concentration-dependent manner. Additionally, pinosylvin was found to inhibit the LPS-induced phosphorylation and degradation of IkappaB alpha in THP-1 cells. Therefore, we have attempted to determine whether pinosylvin can inhibit the expression of cytokines possessing NF-kappaB binding sites in their promoter regions. In a consistent result, pinosylvin inhibited LPS-induced production of TNF alpha and interleukin-8 (IL-8). Taken together, these results show that pinosylvin suppresses the production of pro-inflammatory mediators through the inhibition of the NF-kappaB signaling pathway.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0032-0943eISSN: 1439-0221Titel-ID: cdi_proquest_miscellaneous_68672224
- Format
- –
- Schlagworte
- Anti-Inflammatory Agents - pharmacology, Binding Sites, Cell Line, cultured cells, Cyclooxygenase 2 - genetics, Cyclooxygenase 2 Inhibitors - pharmacology, Cytokines - metabolism, Gene Expression Regulation - drug effects, Genes, Reporter, Humans, I-kappa B Proteins - metabolism, inflammation, interleukin-8, Interleukin-8 - antagonists & inhibitors, Interleukin-8 - genetics, Lipopolysaccharides - antagonists & inhibitors, Luciferases - analysis, NF-kappa B - antagonists & inhibitors, NF-kappa B - metabolism, NF-kappa B - physiology, nuclear factor kappa-B, Phosphorylation, pinosylvin, Pinus - chemistry, Pinus densiflora, Promoter Regions, Genetic, prostaglandin synthase, signal transduction, Signal Transduction - drug effects, stilbenes, Stilbenes - chemistry, Stilbenes - pharmacology, transcription factors, tumor necrosis factor-alpha, Tumor Necrosis Factor-alpha - antagonists & inhibitors, Tumor Necrosis Factor-alpha - genetics