Details

Autor(en) / Beteiligte

• Fried, Iris
• Bar-Oz, Benjamin
• Perles, Zeev
• Rein, Azaria J.J.T.
• Zonis, Zeev
• Nir, Amiram

Titel

N-terminal pro-B–type natriuretic peptide levels in acute versus chronic left ventricular dysfunction

Ist Teil von

• The Journal of pediatrics, 2006-07, Vol.149 (1), p.28-31

Ort / Verlag

New York, NY: Mosby, Inc

Erscheinungsjahr

2006

Quelle

MEDLINE

Beschreibungen/Notizen

• To determine whether acute left ventricular dysfunction (LVD) causes significantly higher elevation of N-terminal pro-B–type natriuretic peptide (NT-proBNP) levels than comparable chronic LVD. Plasma levels of NT-proBNP were measured in 10 pediatric patients diagnosed with acute LVD, in 7 pediatric patients with stable chronic dilated cardiomyopathy (DCM) and comparable levels of echocardiographic dysfunction, and during 5 episodes of acute exacerbation in patients with heart failure. Levels were compared using Mann-Whitney and analysis of variance for rank tests. Plasma levels of NT-proBNP were excessively elevated in patients with acute LVD in the first 24 to 48 hours of hospitalization (median level, 65,600 pg/mL), and were significantly higher than those in patients with chronic DCM (median level, 1125 pg/mL; P < .0001). NT-proBNP levels decreased in the subsequent days in 83% of patients with serial measurements. The NT-proBNP levels were lower In 5 episodes of acute exacerbation than in acute LVD (median level, 7185 pg/mL; P < .003). Acute LVD is associated with elevated NT-proBNP level in children.