Details

Autor(en) / Beteiligte

• Willars, Gary B.

Titel

Mammalian RGS proteins: Multifunctional regulators of cellular signalling

Ist Teil von

• Seminars in cell & developmental biology, 2006-06, Vol.17 (3), p.363-376

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2006

Quelle

MEDLINE

Beschreibungen/Notizen

• Regulators of G-protein signalling (RGS) proteins are a large and diverse family initially identified as GTPase activating proteins (GAPs) of heterotrimeric G-protein Gα-subunits. At least some can also influence Gα activity through either effector antagonism or by acting as guanine nucleotide dissociation inhibitors (GDIs). As our understanding of RGS protein structure and function has developed, so has the realisation that they play roles beyond G-protein regulation. Such diversity of function is enabled by the variety of RGS protein structure and their ability to interact with other cellular molecules including phospholipids, receptors, effectors and scaffolds. The activity, sub-cellular distribution and expression levels of RGS proteins are dynamically regulated, providing a layer of complexity that has yet to be fully elucidated.