Virology (New York, N.Y.), 2005-10, Vol.341 (1), p.102-106
2005
Details
- Autor(en) / Beteiligte
- Titel
- Detection of amantadine-resistant variants among avian influenza viruses isolated in North America and Asia
- Ist Teil von
- Virology (New York, N.Y.), 2005-10, Vol.341 (1), p.102-106
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2005
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Here, we report the diversity of amantadine-resistant mutants among avian influenza A viruses with pandemic potential (H5, H6, H7, and H9 hemagglutinin subtypes). Drug-resistant variants were not detected among 1979–83 isolates, whereas 31.1% of H5 and 10.6% of H9 strains from Southeast Asia isolated in 2000–04 carried mutations in M2 protein. In North America, resistant variants occurred among H7 viruses only (16.4% of those tested). H6 viruses were amantadine-sensitive. These findings prompt concern regarding the control of pandemic influenza, the possibility that the next pandemic virus will be amantadine-resistant and the need to monitor the use of the drug in poultry.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0042-6822eISSN: 1096-0341DOI: 10.1016/j.virol.2005.07.003Titel-ID: cdi_proquest_miscellaneous_68640315
- Format
- –
- Schlagworte
- amantadine, Amantadine - pharmacology, Amantadine resistance, Animals, Antiviral Agents - pharmacology, Asia, Southeastern, Avian influenza A virus, birds, Cell Line, Dogs, drug resistance, Drug Resistance, Viral, genetic variation, Humans, Influenza A virus, Influenza A virus - classification, Influenza A virus - drug effects, Influenza A virus - isolation & purification, Influenza in Birds - drug therapy, Influenza in Birds - virology, Influenza virus, M2 protein, North America, Poultry