Journal of antibiotics, 2006-04, Vol.59 (4), p.241-247
2006
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- Autor(en) / Beteiligte
- Titel
- Syntheses and Pharmacokinetic Studies of Prodrug Esters for the Development of Oral Carbapenem, L-084
- Ist Teil von
- Journal of antibiotics, 2006-04, Vol.59 (4), p.241-247
- Ort / Verlag
- Japan: Nature Publishing Group
- Erscheinungsjahr
- 2006
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- We discovered an orally active carbapenem, L-084, through pharmacokinetic studies on various prodrug esters of (1R,5S,6S)-6-[(R)-1-hydroxyethyl]-l-methyl-2-[1-(1,3-thiazolin-2-yl)azetidin-3-yl]thio-1-carbapen-2-em-3-carboxylic acid (LJC11,036). L-084 showed a strong antimicrobial activity against Gram-positive and Gram-negative bacteria and exhibited the highest intestinal absorption among synthesized prodrugs of LJC11,036.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0021-8820eISSN: 1881-1469DOI: 10.1038/ja.2006.34Titel-ID: cdi_proquest_miscellaneous_68630120
- Format
- –
- Schlagworte
- Administration, Oral, Animals, Anti-Bacterial Agents - administration & dosage, Anti-Bacterial Agents - chemical synthesis, Anti-Bacterial Agents - pharmacokinetics, Anti-Bacterial Agents - pharmacology, Bacteria, Biological Availability, Carbapenems - administration & dosage, Carbapenems - chemical synthesis, Carbapenems - pharmacokinetics, Carbapenems - pharmacology, Carboxylic acids, Esters, Gram-Negative Bacteria - drug effects, Gram-Positive Bacteria - drug effects, Humans, Molecular Structure, Pharmacokinetics, Prodrugs - administration & dosage, Prodrugs - chemical synthesis, Prodrugs - pharmacokinetics, Prodrugs - pharmacology, Rats