Details

Autor(en) / Beteiligte

• Nishimura, Agnes L
• Guindalini, Camila
• Oliveira, João R M
• Nitrini, Ricardo
• Bahia, Valéria S
• de Brito-Marques, Paulo R
• Otto, Paulo A
• Zatz, Mayana

Titel

Monoamine oxidase a polymorphism in Brazilian patients: risk factor for late-onset Alzheimer's disease?

Ist Teil von

• Journal of molecular neuroscience, 2005-01, Vol.27 (2), p.213-218

Ort / Verlag

United States: Springer Nature B.V

Erscheinungsjahr

2005

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Different studies have attempted to find polymorphisms involved in the serotonergic pathway that could be involved in mood disorders and late-onset Alzheimer's disease (LOAD) symptoms. Here, we compared the frequency of two polymorphisms: monoamine oxidase A (MAOA) and serotonin transporter in LOAD patients versus controls. No evidence of association was observed when these polymorphisms were compared separately; however, the combination of the MAOA allele 1+the short allele of 5-HTTLPR+ApoE-epsilon4 was significantly more frequent in patients than in controls. It reinforces the hypothesis that different genes acting together might play a role in AD susceptibility. Based on these data, we suggest replicating these studies in larger samples of LOAD patients belonging to different ethnic groups.