Science (American Association for the Advancement of Science), 2005-09, Vol.309 (5743), p.2067-2070
2005
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Details
- Autor(en) / Beteiligte
- Titel
- Regulation of Mammalian Tooth Cusp Patterning by Ectodin
- Ist Teil von
- Science (American Association for the Advancement of Science), 2005-09, Vol.309 (5743), p.2067-2070
- Ort / Verlag
- Washington, DC: American Association for the Advancement of Science
- Erscheinungsjahr
- 2005
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Mammalian tooth crowns have precise functional requirements but cannot be substantially remodeled after eruption. In developing teeth, epithelial signaling centers, the enamel knots, form at future cusp positions and are the first signs of cusp patterns that distinguish species. We report that ectodin, a secreted bone morphogenetic protein (BMP) inhibitor, is expressed as a "negative" image of mouse enamel knots. Furthermore, we show that ectodin-deficient mice have enlarged enamel knots, highly altered cusp patterns, and extra teeth. Unlike in normal teeth, excess BMP accelerates patterning in ectodin-deficient teeth. We propose that ectodin is critical for robust spatial delineation of enamel knots and cusps.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.1116848Titel-ID: cdi_proquest_miscellaneous_68616455
- Format
- –
- Schlagworte
- Animal teeth, Animals, Biological and medical sciences, Body Patterning, Bone Morphogenetic Protein 4, Bone Morphogenetic Proteins - biosynthesis, Bone Morphogenetic Proteins - genetics, Bone Morphogenetic Proteins - metabolism, Bone Morphogenetic Proteins - pharmacology, Bone Morphogenetic Proteins - physiology, Cell culture, Cell Cycle Proteins - biosynthesis, Cell Cycle Proteins - genetics, Cell Cycle Proteins - physiology, Chimera, Cyclin-Dependent Kinase Inhibitor p21, Dental anthropology, Dental Enamel - embryology, Dentistry, Dentition, Epithelium, Fundamental and applied biological sciences. Psychology, Gene Expression Regulation, Developmental, Genotype & phenotype, Hedgehog Proteins, Heterozygote, Individualized Instruction, Inhibition, Knots, Logical Thinking, Mammalia, Mathematical cusps, Mathematical Models, Mice, Mice, Inbred C57BL, Microscopy, Confocal, Molar - embryology, Molar - metabolism, Mouth. Exocrine and endocrine salivary glands. Teeth. Esophagus, Mutation, Odontogenesis, Organ Culture Techniques, Phenotypes, Physiological regulation, Rodents, Teeth, Tooth Crown - embryology, Tooth enamel, Trans-Activators - biosynthesis, Trans-Activators - genetics, Vertebrates: digestive system