Details

Autor(en) / Beteiligte

• Hjelstuen, Anne
• Anderssen, Sigmund A.
• Holme, Ingar
• Seljeflot, Ingebørg
• Klemsdal, Tor Ole

Titel

Markers of Inflammation Are Inversely Related to Physical Activity and Fitness in Sedentary Men With Treated Hypertension

Ist Teil von

• American journal of hypertension, 2006-07, Vol.19 (7), p.669-675

Ort / Verlag

New York, NY: Elsevier Inc

Erscheinungsjahr

2006

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Physical inactivity is an important risk factor for atherosclerotic disease. We studied the relationship between physical activity and physical fitness and soluble markers of atherosclerotic activity in men with drug-treated hypertension. The participants ( n = 177, 40 to 74 years of age), who were randomly recruited from the Hypertension High Risk Management Trial (HYRIM), were overweight and had sedentary lifestyles. The inflammatory markers high-sensitivity C-reactive protein (hs-CRP), soluble vascular cell adhesion molecule–1 (sVCAM-1), soluble intercellular adhesion molecule-1 (SICAM-1) and soluble E-selectin (sE-selectin) and the hemostatic markers soluble thrombomodulin (sTM), von Willebrand factor (vWf), and tissue plasminogen activator antigen (tPAag) were measured. Physical activity was measured by use of a questionnaire. Time to exhaustion in a bicycle test was used as an expression of physical fitness. The hs-CRP showed a significant inverse relationship with physical fitness independent of major cardiovascular risk factors ( P = .017) but was not related to physical activity. The sE-selectin was significantly related to physical activity, although only when other factors were taken into account ( P = .033), and it had no significant association with physical fitness. In addition there were strong associations between hs-CRP and sICAM-1 and the Framingham Coronary Heart Disease risk score ( P < .001). The observed inverse relations between physical fitness and hs-CRP and between level of physical activity and sE-selectin in drug-treated, hypertensive sedentary men indicates a beneficial effect of good fitness status as well as activity of low intensity on vessel wall inflammation.