Details

Autor(en) / Beteiligte

• Navratilova, Edita
• Eaton, Miriam C.
• Stropova, Dagmar
• Varga, Eva V.
• Vanderah, Todd W.
• Roeske, William R.
• Yamamura, Henry I.

Titel

Morphine promotes phosphorylation of the human δ-opioid receptor at serine 363

Ist Teil von

• European journal of pharmacology, 2005-09, Vol.519 (3), p.212-214

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2005

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• After prolonged stimulation, the δ-opioid receptor becomes desensitized by regulatory mechanisms such as receptor phosphorylation, internalization and down-regulation. In this study, we demonstrate that morphine treatment causes phosphorylation of S 363 in the C-terminus of the human δ-opioid receptor. Morphine-mediated phosphorylation reached 53 ± 8% of maximum deltorphin II-mediated phosphorylation. Phosphorylation of S 363 may contribute to δ-opioid receptor desensitization by morphine.