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BIC and miR-155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas
The Journal of pathology, 2005-10, Vol.207 (2), p.243-249
Kluiver, Joost
Poppema, Sibrand
de Jong, Debora
Blokzijl, Tjasso
Harms, Geert
Jacobs, Susan
Kroesen, Bart-Jan
van den Berg, Anke
2005
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Kluiver, Joost
Poppema, Sibrand
de Jong, Debora
Blokzijl, Tjasso
Harms, Geert
Jacobs, Susan
Kroesen, Bart-Jan
van den Berg, Anke
Titel
BIC and miR-155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas
Ist Teil von
The Journal of pathology, 2005-10, Vol.207 (2), p.243-249
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2005
Quelle
MEDLINE
Beschreibungen/Notizen
In a previous study we demonstrated high expression of the non‐coding BIC gene in the vast majority of Hodgkin's lymphomas (HLs). Evidence suggesting that BIC is a primary microRNA transcript containing the mature microRNA‐155 (miR‐155) as part of a RNA hairpin is now accumulating. We therefore analysed HL cell lines and tissue samples to determine whether miR‐155 is also expressed in HL. High levels of miR‐155 could be demonstrated, indicating that BIC is processed into a microRNA in HL. Most non‐HL subtypes were negative for BIC as determined by RNA‐ISH. However, in diffuse large B cell lymphoma (DLBCL) and primary mediastinal B cell lymphoma (PMBL), significant percentages of positive tumour cells were observed in 12/18 and 8/8 cases. A higher proportion of tumour cells were positive for BIC in DLBCL with activated B cell‐like phenotype than in DLBCL with germinal centre B cell‐like phenotype. Differential BIC expression was confirmed by qRT‐PCR analysis. Northern blot analysis showed expression of miR‐155 in all DLBCL and PMBL derived cell lines and tissue samples analysed. In summary, we demonstrate expression of primary microRNA BIC and its derivative miR‐155 in HL, PMBL and DLBCL. Copyright © 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 0022-3417
eISSN: 1096-9896
DOI: 10.1002/path.1825
Titel-ID: cdi_proquest_miscellaneous_68576475
Format
–
Schlagworte
BIC
,
Cell Line, Tumor
,
diffuse large B cell lymphoma
,
Hodgkin Disease - genetics
,
Hodgkin's lymphoma
,
Humans
,
Immunohistochemistry - methods
,
In Situ Hybridization - methods
,
Lymphoma - genetics
,
Lymphoma, B-Cell - genetics
,
Lymphoma, Large B-Cell, Diffuse - genetics
,
Mediastinal Neoplasms - genetics
,
microRNA
,
microRNA-155
,
MicroRNAs - genetics
,
primary mediastinal B cell lymphoma
,
Receptors, Antigen, B-Cell - genetics
,
Reverse Transcriptase Polymerase Chain Reaction - methods
,
RNA, Neoplasm - genetics
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