Details

Autor(en) / Beteiligte

• Tinsley, Jennifer M
• Mertz, Eric
• Chong, Pek Y
• Rarig, Robert-André F
• Roush, William R

Titel

Synthesis of (+)-Bullatacin via the Highly Diastereoselective [3+2] Annulation Reaction of a Racemic Aldehyde and a Nonracemic Allylsilane

Ist Teil von

• Organic letters, 2005-09, Vol.7 (19), p.4245-4248

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2005

Quelle

MEDLINE

Beschreibungen/Notizen

• A total synthesis of (+)-bullatacin has been accomplished via a diastereoselective [3+2] annulation reaction of the highly enantiomerically enriched allylsilane 3 and racemic aldehyde 4, which provides the key bis-tetrahydrofuran fragment 15 with ≥20:1 ds.