Details

Autor(en) / Beteiligte

• Hohlfeld, Judith
• de Buys Roessingh, Anthony
• Hirt-Burri, Nathalie
• Chaubert, Pascal
• Gerber, Stefan
• Scaletta, Corinne
• Hohlfeld, Patrick
• Applegate, Lee Ann

Titel

Tissue engineered fetal skin constructs for paediatric burns

Ist Teil von

• The Lancet (British edition), 2005-09, Vol.366 (9488), p.840-842

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2005

Quelle

EBSCOhost Business Source Ultimate

Beschreibungen/Notizen

• Autologous skin-grafting is the gold standard for treatment of deep second and third degree burns. Available bioengineered skin products also necessitate this two-step surgical procedure. Therefore, we developed fetal skin constructs to improve healing of such degree burns. A bank of fetal skin cells was developed from one organ donation (4 cm 2 of skin allowing the preparation of several million three-dimensional skin constructs, 9×12 cm, on native horse collagen). Successive fetal constructs were applied to eight patients at every change of dressing during 1–3 weeks in an outpatient setting. Complete closure was rapid (mean 15·3 days [SD 5·5]) with little hypertrophy of new skin and no retraction seen. This simple technique provided complete treatment without auto-grafting, showing that fetal skin cells might have great potential to treat burns and eventually acute and chronic wounds of other types.