Nature neuroscience, 2005-09, Vol.8 (9), p.1139-1141
2005
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- Autor(en) / Beteiligte
- Titel
- Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus
- Ist Teil von
- Nature neuroscience, 2005-09, Vol.8 (9), p.1139-1141
- Ort / Verlag
- United States: Nature Publishing Group
- Erscheinungsjahr
- 2005
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The functions of 2-arachidonoylglycerol (2-AG), the most abundant endocannabinoid found in the brain, remain largely unknown. Here we show that two previously unknown inhibitors of monoacylglycerol lipase, a presynaptic enzyme that hydrolyzes 2-AG, increase 2-AG levels and enhance retrograde signaling from pyramidal neurons to GABAergic terminals in the hippocampus. These results establish a role for 2-AG in synaptic plasticity and point to monoacylglycerol lipase as a possible drug target.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1097-6256eISSN: 1546-1726DOI: 10.1038/nn1521Titel-ID: cdi_proquest_miscellaneous_68525107
- Format
- –
- Schlagworte
- Aniline Compounds, Animals, Arachidonic Acids - antagonists & inhibitors, Arachidonic Acids - metabolism, Benzoxazines, Cannabinoid Receptor Modulators, Dose-Response Relationship, Drug, Endocannabinoids, Enzyme Inhibitors - chemistry, Enzyme Inhibitors - pharmacology, GABA, Glycerides - antagonists & inhibitors, Glycerides - metabolism, HeLa Cells, Hippocampus (Brain), Hippocampus - cytology, Humans, Hydrolysis - drug effects, In Vitro Techniques, Membrane Potentials - drug effects, Membrane Potentials - physiology, Monoacylglycerol Lipases - metabolism, Monoglycerides, Neural Inhibition - drug effects, Patch-Clamp Techniques - methods, Physiological aspects, Pyramidal Cells - drug effects, Pyramidal Cells - physiology, Rats, Signal Transduction - drug effects