Details

Autor(en) / Beteiligte

• Trovato, Antonio
• Seno, Flavio
• Tosatto, Silvio C.E.

Titel

The PASTA server for protein aggregation prediction

Ist Teil von

• Protein engineering, design and selection, 2007-10, Vol.20 (10), p.521-523

Ort / Verlag

England: Oxford University Press

Erscheinungsjahr

2007

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Many different proteins aggregate into amyloid fibrils characterized by cross-β structure. β-strands contributed by distinct protein molecules are generally found in a parallel in-register alignment. Here, we describe the web server for a novel algorithm, prediction of amyloid structure aggregation (PASTA), to predict the most aggregation-prone portions and the corresponding β-strand inter-molecular pairing for a given input sequence. PASTA was previously shown to yield results in excellent agreement with available experimental observations, when tested on both natively unfolded and structured proteins. The web server and downloadable source code are freely accessible from the URL: http://protein.cribi.unipd.it/pasta/.