Details

Autor(en) / Beteiligte

• HOUSHMAND, Massoud
• BANOEI, Mohammad Mehdi
• TABARSI, Payam
• PANAHI, Mehdi Shafa Shariat
• KASHANI, Baharak Hooshiar
• EBRAHIMI, Golnaz
• ZARGAR, Laleh
• FARNIA, Parissa
• MORRIS, Matthew W.
• MANSOURI, Davood
• VELAYATI, Ali Akbar
• MIRSAEIDI, Mehdi S.

Titel

Do mitochondrial DNA haplogroups play a role in susceptibility to tuberculosis?

Ist Teil von

• Respirology (Carlton, Vic.), 2007-11, Vol.12 (6), p.823-827

Ort / Verlag

Melbourne, Australia: Blackwell Publishing Asia

Erscheinungsjahr

2007

Quelle

MEDLINE

Beschreibungen/Notizen

• Background and objectives:  Mitochondrial DNA has a unique role in ATP production and subsequent mitochondrial reactive oxygen species (ROS) production in eukaryotic cells and there is a potential role for ROS and oxygen burst against Mycobacterium tuberculosis, an intracellular pathogen. This study aimed to determine whether the frequency of different mitochondrial haplogroups was significantly different in patients with tuberculosis (TB) compared with a normal population. Methods:  Mitochondrial DNA haplogroups M, N, J and K were studied by PCR‐restriction fragment length polymorphism and sequencing. Cases were 54 patients with confirmed smear positive pulmonary TB. Controls were 256 healthy persons. Results:  There were no statistically significant differences between those with TB and the control group. Conclusions:  There was no statistically significant association between mtDNA haplogroups and the presence of TB infection.