Bioorganic & medicinal chemistry, 2007-12, Vol.17 (23), p.6467-6471
2007
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Details
- Autor(en) / Beteiligte
- Titel
- 2-Aryl benzimidazoles featuring alkyl-linked pendant alcohols and amines as inhibitors of checkpoint kinase Chk2
- Ist Teil von
- Bioorganic & medicinal chemistry, 2007-12, Vol.17 (23), p.6467-6471
- Ort / Verlag
- Oxford: Elsevier Ltd
- Erscheinungsjahr
- 2007
- Quelle
- Elsevier ScienceDirect Journals
- Beschreibungen/Notizen
- A series of benzimidazole compounds containing pendant alcohol and amine moieties was found to be active against checkpoint kinase Chk2. These compounds were prepared to examine a potential hydrogen bond interaction with an active site residue and to investigate replacement of a biaryl linker with an aliphatic system in an effort to improve solubility.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894X, 0968-0896eISSN: 1464-3405, 1464-3391DOI: 10.1016/j.bmcl.2007.09.098Titel-ID: cdi_proquest_miscellaneous_68477239
- Format
- –
- Schlagworte
- Alcohols - chemistry, Alcohols - pharmacology, Amines - chemistry, Amines - pharmacology, Aminoalcohol, Antineoplastic agents, Benzimidazoles - chemistry, Benzimidazoles - pharmacology, Biological and medical sciences, Cds1, Checkpoint Kinase 2, Chk2, General aspects, Hydrogen Bonding, Medical sciences, Mitsunobu, Pharmacology. Drug treatments, Protein Kinase Inhibitors - chemistry, Protein Kinase Inhibitors - pharmacology, Protein-Serine-Threonine Kinases - antagonists & inhibitors, Solubility