Details

Autor(en) / Beteiligte

• Jacob, James R. (Cornell University, Ithaca, NY, USA)
• Mansfield, Keith (New England Regional Primate Research Center, Harvard Medical School, MA, USA)
• You, J.E. (The University of Suwon, Hwaseong, Republic of Korea)
• Tennant, Bud C. (Cornell University, Ithaca, NY, USA)
• Kim, Y.H. (The University of Suwon, Hwaseong, Republic of Korea), E-mail: kimyh@suwon.ac.kr

Titel

Natural Iminosugar Derivatives of 1-Deoxynojirimycin Inhibit Glycosylation of Hepatitis Viral Envelope Proteins

Ist Teil von

• The journal of microbiology, 2007-10, Vol.45 (5), p.431-440

Ort / Verlag

Korea (South)

Erscheinungsjahr

2007

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• A silkworm (Bombyx mori L.) extract known to contain naturally occurring iminosugars, including 1-deoxynojirimycin (1-DNJ) derived from the mulberry tree (Morus alba L.), was evaluated in surrogate HCV and HBV in vitro assays. Antiviral activity of the silkworm extract and one of its purified constituents, 1-DNJ, was demonstrated against bovine viral diarrhea virus (BVDV) and GB virus-B (GBV-B), both members of the Flaviviridae family, and against woodchuck hepatitis virus (WHV) and hepatitis B virus (HBV), both members of the Hepadnaviridae family of viruses.