Developmental cell, 2007-11, Vol.13 (5), p.677-690
2007
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Mammalian SEPT2 Is Required for Scaffolding Nonmuscle Myosin II and Its Kinases
- Ist Teil von
- Developmental cell, 2007-11, Vol.13 (5), p.677-690
- Ort / Verlag
- Cambridge, MA: Elsevier Inc
- Erscheinungsjahr
- 2007
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Mammalian septin SEPT2 belongs to a conserved family of filamentous GTPases that are associated with actin stress fibers in interphase cells and the contractile ring in dividing cells. Although SEPT2 is essential for cytokinesis, its role in this process remains undefined. Here, we report that SEPT2 directly binds nonmuscle myosin II (myosin II), and this association is important for fully activating myosin II in interphase and dividing cells. Inhibition of the SEPT2-myosin II interaction in interphase cells results in loss of stress fibers, while in dividing cells this causes instability of the ingressed cleavage furrow and dissociation of the myosin II from the Rho-activated myosin kinases ROCK and citron kinase. We propose that SEPT2-containing filaments provide a molecular platform for myosin II and its kinases to ensure the full activation of myosin II that is necessary for the final stages of cytokinesis.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1534-5807eISSN: 1878-1551DOI: 10.1016/j.devcel.2007.09.001Titel-ID: cdi_proquest_miscellaneous_68468447
- Format
- –
- Schlagworte
- Animals, Biological and medical sciences, Cell differentiation, maturation, development, hematopoiesis, Cell physiology, CELLBIO, CHO Cells, Cricetinae, Cricetulus, Cytokinesis, Fundamental and applied biological sciences. Psychology, GTP Phosphohydrolases - physiology, Intracellular Signaling Peptides and Proteins - metabolism, Molecular and cellular biology, Myosin Type II - metabolism, Protein Binding, Protein Folding, Protein-Serine-Threonine Kinases - metabolism, rho-Associated Kinases - metabolism