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Chromatin Modifications as Targets for New Anticancer Drugs
Ist Teil von
Archiv der Pharmazie (Weinheim), 2005-08, Vol.338 (8), p.347-357
Ort / Verlag
Weinheim: WILEY-VCH Verlag
Erscheinungsjahr
2005
Link zum Volltext
Quelle
Wiley Online Library All Journals
Beschreibungen/Notizen
Chromatin proteins undergo diverse posttranslational modifications, esp. acetylation and methylation, that contribute to the control of transcriptional processes. The result of these modifications in its various states is called the histone code. This review presents an overview of those modifications of chromatin proteins that affect the side chains of lysines and arginines and define variations of the chromatin acetylome and methylome. The relevant enzymes are presented and the feasibility to influence their activity by inhibition or activation is discussed. The manipulation of these enzymes is an exciting strategy towards an increased understanding of their role in the functionality of a cell. Additionally, this may lead to new approaches for the treatment of diseases that are based on a dysregu lation of transcription, especially cancer.