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Journal of clinical oncology, 2005-08, Vol.23 (23), p.5334-5346

2005

Autor(en) / Beteiligte

Titel

Thalidomide Downregulates Angiogenic Genes in Bone Marrow Endothelial Cells of Patients With Active Multiple Myeloma

Ist Teil von

Ort / Verlag

United States: American Society of Clinical Oncology

Erscheinungsjahr

2005

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

To study the antiangiogenic effect of thalidomide. The expression of key angiogenic genes was studied in bone marrow endothelial cells (ECs) of patients with active and nonactive multiple myeloma (MM), monoclonal gammopathies unattributed/unassociated (MG[u]), diffuse large B-cell non-Hodgkin's lymphoma, in a Kaposi's sarcoma (KS) cell line, and in healthy human umbilical vein ECs (HUVECs) following exposure to therapeutic doses of thalidomide. Thalidomide markedly downregulates the genes in a dose-dependent fashion in active MMECs and KS cell line, but upregulates them or is ineffective in nonactive MMECs, MG(u)ECs, NHL-ECs, and in HUVECs. Secretion of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and hepatocyte growth factor also diminishes according to the dose in culture conditioned media (CM) of active MMECs and KS, whereas it does not change in the other CM. Inhibition by thalidomide is probably confined to the genes of active MMECs and KS. This would account for its higher efficacy in these diseases.

Sprache: Englisch
Identifikatoren: ISSN: 0732-183X
eISSN: 1527-7755
DOI: 10.1200/JCO.2005.03.723
Titel-ID: cdi_proquest_miscellaneous_68462045

Format: –
Schlagworte: Adult, Aged, Aged, 80 and over, Angiogenesis Inhibitors - pharmacology, Bone Marrow - pathology, Cells, Cultured, Culture Media, Conditioned, Down-Regulation, Endothelium, Vascular - drug effects, Endothelium, Vascular - metabolism, Endothelium, Vascular - pathology, Enzyme-Linked Immunosorbent Assay, Female, Fibroblast Growth Factor 2 - genetics, Fibroblast Growth Factor 2 - metabolism, Gene Expression Profiling, Hepatocyte Growth Factor - genetics, Hepatocyte Growth Factor - metabolism, Humans, Lymphoma, B-Cell - drug therapy, Lymphoma, B-Cell - genetics, Lymphoma, B-Cell - metabolism, Lymphoma, Large B-Cell, Diffuse - drug therapy, Male, Middle Aged, Multiple Myeloma - drug therapy, Multiple Myeloma - genetics, Multiple Myeloma - metabolism, Paraproteinemias - drug therapy, Paraproteinemias - genetics, Paraproteinemias - metabolism, RNA, Messenger - metabolism, RNA, Neoplasm - metabolism, Sarcoma, Kaposi - drug therapy, Sarcoma, Kaposi - genetics, Sarcoma, Kaposi - metabolism, Thalidomide - pharmacology, Umbilical Veins - metabolism, Vascular Endothelial Growth Factor A - genetics, Vascular Endothelial Growth Factor A - metabolism

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