The Journal of infectious diseases, 2005-09, Vol.192 (5), p.771-782
2005
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Evolutionary Origin and Emergence of a Highly Successful Clone of Serotype M1 Group A Streptococcus Involved Multiple Horizontal Gene Transfer Events
- Ist Teil von
- The Journal of infectious diseases, 2005-09, Vol.192 (5), p.771-782
- Ort / Verlag
- Chicago, IL: The University of Chicago Press
- Erscheinungsjahr
- 2005
- Quelle
- Oxford Journals 2020 Medicine
- Beschreibungen/Notizen
- To better understand the molecular events involved in the origin of new pathogenic bacteria, we studied the evolution of a highly virulent clone of serotype M1 group A Streptococcus (GAS). Genomic, DNA-DNA microarray, and single-nucleotide polymorphism analyses indicated that this clone evolved through a series of horizontal gene transfer events that involved (1) the acquisition of prophages encoding streptococcal pyrogenic exotoxin A and extracellular DNases and (2) the reciprocal recombination of a 36-kb chromosomal region encoding the extracellular toxins NAD+-glycohydrolase (NADase) and streptolysin O (SLO). These gene transfer events were associated with significantly increased production of SLO and NADase. Virtual identity in the 36-kb region present in contemporary serotype M1 and M12 isolates suggests that a serotype M12 strain served as the donor of this region. Multiple horizontal gene transfer events were a crucial factor in the evolutionary origin and emergence of a very abundant contemporary clone of serotype M1 GAS
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0022-1899eISSN: 1537-6613DOI: 10.1086/432514Titel-ID: cdi_proquest_miscellaneous_68461902
- Format
- –
- Schlagworte
- Antigens, Bacterial - genetics, Bacteria, Bacterial Outer Membrane Proteins - genetics, Bacterial Proteins - genetics, Bacterial Proteins - metabolism, Bacteriology, Base Sequence, Biological and medical sciences, Blood, Carrier Proteins - genetics, Clone Cells, DNA, Bacterial - chemistry, DNA, Bacterial - genetics, Fundamental and applied biological sciences. Psychology, Gene Transfer, Horizontal - genetics, Genes, Genome, Bacterial, Genomes, Genotypes, Horizontal gene transfer, Humans, Infections, Infectious diseases, Medical sciences, Microbiology, Miscellaneous, Molecular Sequence Data, NAD+ Nucleosidase - genetics, NAD+ Nucleosidase - metabolism, Nucleic Acid Hybridization, Oligonucleotide Array Sequence Analysis, Open reading frames, Phylogeny, Polymorphism, Single Nucleotide - genetics, Promoter regions, Prophages, Sequence Analysis, DNA, Streptococcal Infections - genetics, Streptococcal Infections - microbiology, Streptococcus, Streptococcus pyogenes - enzymology, Streptococcus pyogenes - genetics, Streptolysins - genetics, Streptolysins - metabolism