Details

Autor(en) / Beteiligte

• Körbling, M.
• Robinson, S.
• Estrov, Z.
• Champlin, R.
• Shpall, E.

Titel

Umbilical cord blood-derived cells for tissue repair

Ist Teil von

• Cytotherapy (Oxford, England), 2005, Vol.7 (3), p.258-261

Ort / Verlag

England: Elsevier Inc

Erscheinungsjahr

2005

Quelle

MEDLINE

Beschreibungen/Notizen

• Hematopoietic tissue-derived cells, including stem cells, have been shown to generate solid organ tissue-specific cells. Besides bone marrow and peripheral blood, umbilical cord blood (UCB) has the advantage of being an easily accessible stem cell source provided as a banked cell product. Using the xenogeneic human into NOD/SCID mouse stem cell transplant model preliminary data suggest UCB-derived tissue-specific cells generated in liver, pancreas, CNS and endothelium. In a clinical sex-mismatched UCB transplant setting Y-positive, UCB-derived gastrointestinal epithelial cells and CNS-specific cells have been identified in female patients. The potential therapeutic use of UCB cells for tissue repair is, however, limited by a low total stem cell number available and by HLA-disparity.