Details

Autor(en) / Beteiligte

• Xia, Xue-Kui
• Huang, Hua-Rong
• She, Zhi-Gang
• Shao, Chang-Lun
• Liu, Fan
• Cai, Xiao-Ling
• Vrijmoed, L L P
• Lin, Yong-Cheng

Titel

(1)H and (13)C NMR assignments for five anthraquinones from the mangrove endophytic fungus Halorosellinia sp. (No. 1403)

Ist Teil von

• Magnetic resonance in chemistry, 2007-11, Vol.45 (11), p.1006-1009

Ort / Verlag

England

Erscheinungsjahr

2007

Quelle

MEDLINE

Beschreibungen/Notizen

• We report the unambiguous assignments of the (1)H and (13)C NMR spectra of two new natural products, namely, 1,4,5,6,7,9-hexahydroxy-2-methoxy-7-methyl-5beta,9beta,8abeta, 6alpha,10aalpha-hexahydroanthracen-10 (10aH)-one (1) and 1,4,6-trihydroxy-2-methoxy-7-methylanthracene-9, 10-dione (2), together with three known anthraquinones. These compounds were all isolated from the marine endophytic fungus No. 1403 collected from the South China Sea. Compounds 3 and 4 were isolated from the marine fungus for the first time. The structures were elucidated by the spectroscopic methods 1D and 2D NMR including COSY, HMQC, HMBC and NOE, and HREIMS. In our cytotoxicity assays, compound 5 showed cytotoxicity toward KB and KBv-200 cells with IC(50) of 1.40 and 2.58 microg/ml, respectively. In addition, the plausible biogenic relationship of compounds 1, 2, 3 and 4 is discussed.