Details

Autor(en) / Beteiligte

• Völzke, Henry
• Friedrich, Nele
• Schipf, Sabine
• Haring, Robin
• Lüdemann, Jan
• Nauck, Matthias
• Dörr, Marcus
• Brabant, Georg
• Wallaschofski, Henri

Titel

Association between Serum Insulin-Like Growth Factor-I Levels and Thyroid Disorders in a Population-Based Study

Ist Teil von

• The journal of clinical endocrinology and metabolism, 2007-10, Vol.92 (10), p.4039-4045

Ort / Verlag

Bethesda, MD: Endocrine Society

Erscheinungsjahr

2007

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Objective: There is current debate on whether serum IGF-I levels are associated with thyroid disorders. The aims of the present study were: 1) to investigate possible associations between serum IGF-I levels and thyroid disorders and 2) to analyze the role of serum IGF binding protein (IGFBP)-3 and TSH levels for these associations. Design: This was a cross-sectional Study of Health in Pomerania. Setting: The study was conducted in the general population of northeast Germany. Subjects: The study population comprised 3662 subjects (1746 women) without history of thyroid disorders. Interventions: No interventions have been performed. Main Outcome Measures: Goiter and thyroid nodules were determined by ultrasound. Serum TSH levels less than 0.25 mIU/liter were considered decreased. Results: Adjusted for major confounders and risk factors for thyroid disorders, subjects with serum IGF-I levels above the upper tertile had higher odds for goiter relative to subjects with serum IGF-I levels below the lower tertile [odds ratio (OR) 1.67; 95% confidence interval (CI) 1.24–2.26 in women; OR 2.04; 95% CI 1.55–2.68 in men]. A similar association was present for thyroid nodules in men (OR 1.64; 95% CI 1.17–2.32) and for decreased serum TSH levels in women (OR 1.65; 95% CI 1.00–2.69). Serum IGFBP-3 levels were not associated with thyroid disorders and did not represent effect modifiers for the association between serum IGF-I levels and the endpoints. Conclusions: We conclude that high serum IGF-I levels are associated with goiter. Whereas high serum IGF-I levels are also related to thyroid nodules in men, they are related to decreased serum TSH levels in women. Serum IGFBP-3 and TSH levels did not modulate these associations.