Details

Autor(en) / Beteiligte

• Park, So Young
• Hong, Seong Su
• Han, Xiang Hua
• Hwang, Ji Sang
• Lee, Dongho
• Ro, Jai Seup
• Hwang, Bang Yeon

Titel

Lignans from Arctium lappa and Their Inhibition of LPS-Induced Nitric Oxide Production

Ist Teil von

• Chemical and Pharmaceutical Bulletin, 2007, Vol.55(1), pp.150-152

Ort / Verlag

Japan: The Pharmaceutical Society of Japan

Erscheinungsjahr

2007

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• A new butyrolactone sesquilignan, isolappaol C (1), together with four known lignans, lappaol C (2), lappaol D (3), lappaol F (4), and diarctigenin (5), were isolated from the methanolic extract of the seeds from the Arctium lappa plant. The structure of isolappaol C (1) was determined by spectral analysis including 1D- and 2D-NMR. All the isolates were evaluated for their inhibitory effects on the LPS-induced nitric oxide production using murine macrophage RAW264.7 cells. Lappaol F (4) and diarctigenin (5) strongly inhibited NO production in the LPS-stimulated RAW264.7 cells with IC50 values of 9.5 and 9.6 μM, respectively.