Details

Autor(en) / Beteiligte

• Qin, Hua-Li
• Lowe, Jason T
• Panek, James S

Titel

Mild Reductive Opening of Aryl Pyranosides Promoted by Scandium(III) Triflate

Ist Teil von

• Journal of the American Chemical Society, 2007-01, Vol.129 (1), p.38-39

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2007

Quelle

MEDLINE

Beschreibungen/Notizen

• An efficient method for the nucleophilic ring opening of stereochemically well-defined aryl pyranosides is described. The reaction effects a formal deoxygenation of the benzylic position to provide useful, enantioenriched building blocks. To illustrate the utility of the Sc(OTf)3-promoted ring opening, a short synthesis of the C11−C21 fragment of reblastatin and geldanamycin is described.